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Extremely preterm (EPT)/extremely low-birth-weight (ELBW) youngsters attaining faculty age and adolescence usually have issues with govt features equivalent to working reminiscence and selective consideration. Our purpose was to research a hypothesized distinction in blood oxygen stage-dependent (Bold) activation throughout a selective attention-working reminiscence activity in EPT/ELBW kids as compared with time period-born controls. A regional cohort of 28 EPT/ELBW children and 28 term-born controls underwent useful magnetic resonance imaging (fMRI) scanning at 11 y of age while performing a combined Stroop n-again process. Group variations in Bold activation had been analyzed with Statistical Parametric Mapping 8 evaluation software package deal, and reaction instances (RTs) and response accuracy (RA) had been in contrast in a multifactorial ANOVA test. The Bold activation sample in the preterm group concerned the same areas (cingulate, prefrontal, and parietal cortexes), however all areas displayed significantly much less activation than these within the control group, significantly when the cognitive load was increased. The RA results corresponded with the activation information in that the preterm group had considerably fewer appropriate responses. No group difference was discovered regarding RTs. Children born EPT/ELBW displayed reduced working memory and selective consideration capacity as in contrast with term-born controls. These impairments had neuronal correlates with diminished Bold activation in areas liable for online stimulus monitoring, working reminiscence, and cognitive control.
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發表於 2025-9-26 10:16:27