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"Our work challenges the textbook mannequin of how the mind fuels itself. Neurons are more self-adequate than we thought," Singh mentioned. Co-author Daniel Colón-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at YSM, stated the research helps the notion of glycogen as an "energy capacitor" in neurons. "Just like in muscles, this reserve can buffer fast shifts in vitality demand," Colón-Ramos said. Other authors, all from Yale, include Sarah Emerson, a postdoctoral researcher in neuroscience; Ian J. Gonzalez, a graduate scholar in cell biology; Anjali A. Vishwanath and Anastasia Tsives, put up-doctoral researchers in neuroscience; and Richard Goodman, a analysis scientist in neuroscience. Original Research: Open access. "Glycogen supports glycolytic plasticity in neurons" by Milind Singh et al. Glycogen is the biggest power reserve within the mind, but the precise role of glycogen in supporting neuronal vitality metabolism in vivo isn't nicely understood. We carried out an RNAi screen and identified that PYGL-1, an ortholog of the human glycogen phosphorylase, is required in neurons for glycolytic plasticity. We determined that neurons make use of not less than two mechanisms of glycolytic plasticity: glycogen-dependent glycolytic plasticity (GDGP) and glycogen-impartial glycolytic plasticity. We uncover that GDGP is employed under conditions of mitochondrial dysfunction, resembling transient hypoxia or in mutants for mitochondrial operate.
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