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Background: Physical exercise has been long acknowledged for its therapeutic effects on depressive disorders, but the underlying mechanisms remain largely unknown. In the examine, we investigated whether or not the physical exercise by voluntary wheel operating (VWR) alters depression-like behaviors and its influence on mind Blood Vitals oxygen degree-dependent (Bold) alerts in mice. Ex. The variations in useful mind modifications were decided by Bold functional magnetic resonance imaging (fMRI). Results: The outcomes confirmed that VWR train significantly reversed the CUMS-induced behavioral abnormalities. Base on the fMRI amplitude of low-frequency fluctuation (ALFF) evaluation, we found that VWR exercise may restore the CUMS-induced extreme Bold activation in elements of limbic system, such as cortex, hippocampus and corpus callosum. Furthermore, CUMS-induced Bold suppressive areas had been also partially attenuated by VWR exercise, comparable to amygdala, cerebellum anterior lobe, thalamus, midbrain, and pontine. Most of these regions are involved in mood-regulating circuit, suggesting dysfunction of the circuit in CUMS mannequin of depression, and VWR train could regulate the mood-regulating circuit. |
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