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"Our work challenges the textbook model of how the brain fuels itself. Neurons are more self-sufficient than we thought," Singh mentioned. Co-creator Daniel Colón-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at YSM, stated the examine helps the notion of glycogen as an "energy capacitor" in neurons. "Just like in muscles, this reserve can buffer rapid shifts in vitality demand," Colón-Ramos said. Other authors, all from Yale, embrace Sarah Emerson, a postdoctoral researcher in neuroscience; Ian J. Gonzalez, a graduate pupil in cell biology; Anjali A. Vishwanath and Anastasia Tsives, submit-doctoral researchers in neuroscience; and Richard Goodman, a research scientist in neuroscience. Original Research: Open access. "Glycogen helps glycolytic plasticity in neurons" by Milind Singh et al. Glycogen is the most important power reserve within the mind, but the precise function of glycogen in supporting neuronal vitality metabolism in vivo is not nicely understood. We carried out an RNAi screen and recognized that PYGL-1, an ortholog of the human glycogen phosphorylase, is required in neurons for glycolytic plasticity. We decided that neurons employ a minimum of two mechanisms of glycolytic plasticity: glycogen-dependent glycolytic plasticity (GDGP) and glycogen-impartial glycolytic plasticity. We uncover that GDGP is employed beneath conditions of mitochondrial dysfunction, corresponding to transient hypoxia or in mutants for mitochondrial operate.

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